Direct Experimental Evidence For Competitive Inhibition Of Dihydrofolate Reductase By Methotrexate
This research provides direct experimental evidence confirming that methotrexate functions as a competitive inhibitor of dihydrofolate reductase (DHFR). Understanding this specific mechanism is crucial for comprehending methotrexate's pharmacological actions and its implications in therapeutic applications, particularly in cancer treatment and autoimmune diseases.