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This crucial area of study delves into the intricate processes of drug transport mechanisms and the development of resistance within both antimicrobial and anticancer chemotherapy. Understanding how therapeutic agents reach their targets and the multifaceted ways cells develop immunity to these drugs, often involving drug efflux pumps or altered cellular pathways, is vital for overcoming chemotherapy resistance and designing more effective treatments in the future.

This research investigates the strategic application of interferon modulators to address and overcome partial resistance observed in human ovarian cancers to VSV GP oncolytic viral therapy. By modulating the immune response, this approach seeks to enhance the efficacy of viral therapy, offering a promising new strategy for improving patient outcomes in challenging ovarian cancer cases.